Mouse TREML4/TLT-4 Biotinylated Antibody

TREML4 (Triggering receptor expressed on myeloid cells-like 4; also TLT4) is a 29 kDa (predicted) member of the Ig superfamily. It is likely expressed by leukocytes and based on its structure, may act as an activating receptor. Mature mouse TREML4 is a type I transmembrane (TM) protein 235 amino acids (aa) in length. It contains a 171 aa extracellular region (aa 29‑199) with a V-type Ig-like domain (aa 29‑122); the TM segment contains one Lys residue. There is one splice variant that shows a deletion of aa 21‑24, a segment that lies in the putative signal sequence. Rodent and human TREML4 are highly divergent and thus over aa 25‑195, mouse TREML4 shares 78% aa identity with rat TREML4, but only 52% aa identity with human TREML4.