Mouse VE-Statin Isoform 1 Antibody

Mouse VE-Statin (vascular endothelial cell statin; also EGFL7) is a secreted glycoprotein that belongs to an expanding family of EGF-like domain-containing proteins. It typically runs at 33-36 kDa in SDS-PAGE.  Higher molecular weight monomers ranging from 40-42 kDa have also been reported, and suggested to be a consequence of O-linked glycosylation.  VE-Statin is an early marker of embryonic endothelial cells, and occurs in adult endothelium. Its secretion blocks smooth muscle migration. The mature molecule is 254 amino acids (aa) in length, and contains one N-terminal EMI domain (aa 28‑105), two EGF-like domains (aa 106‑178), and a coiled‑coil region (aa 196‑220). There is at least one isoform that shows a 13 aa deletion between aa 236‑248. Mature mouse VE-statin shares 76% and 80% aa sequence identity with dog and human VE‑statin, respectively.