MRP2 Antibody (M2III-6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-42349

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human, Rat

Cited:

Rat

Applications

Validated:

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Frozen

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # M2III-6

Concentration

0.1 mg/ml

View all MRP2 Antibodies »

Product Specifications

Immunogen

202-amino acid sequence at C-terminal end of MRP2

Reactivity Notes

Use in Rat reported in scientific literature (PMID: 32697600).

Specificity

Reacts with an internal epitope of MRP2. Does not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for MRP2 Antibody (M2III-6)

Application
Recommended Usage

Flow Cytometry

1:10-1:1000

Immunocytochemistry/ Immunofluorescence

1:20-1:50

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Frozen

1:20

Immunohistochemistry-Paraffin

1:20

Western Blot

1:20-1:50
Application Notes
M2III-6 has potential value for detection of MRP2-mediated drug-resistance in human tumor samples. Immunocytochemistry: use 1:20-50 dil. on acetone fixed cytospin preparations. For immunohistochemistry: M2III-6 (use 1:20) on acetone fixed frozen sections

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS, 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: MRP2

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Long Name

Multi-drug Resistance Protein 2

Alternate Names

ABC30, ABCC2, CMOAT, CMOAT1, cMRP

Entrez Gene IDs

1244 (Human)

Gene Symbol

ABCC2

UniProt

Q92887 (Human)

Additional MRP2 Products

Product Documents for MRP2 Antibody (M2III-6)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MRP2 Antibody (M2III-6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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