MRP3 Antibody (M3II-21)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-42348

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Simple Western, Western Blot

Cited:

Simple Western

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # M3II-21

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all MRP3 Antibodies »

Product Specifications

Immunogen

MRP3 (aa 830-949)

Specificity

Reacts with an internal epitope of MRP3. Does not cross-react with the human MDR1, MRP1, MRP2 or MRP5 gene products

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for MRP3 Antibody (M3II-21)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:20-1:50

Immunohistochemistry

1:20

Immunohistochemistry-Frozen

1:20

Western Blot

1:20-1:50
Application Notes
M3II-21 has potential value for detection of MRP3-mediated drug-resistance in human tumor samples. Immunocytochemistry: use 1:20-1:50 dil. on acetone or formaldehyde fixed cytospin preparations. For immunohistochemistry: use 1:20 on acetone fixed frozen sections. Western Blot: use 1:20-1:50 dil, and anti-Mouse HRP. Flow Cytometry: optimal conditions still to be defined. Use in Simple Western reported in scientific literature (PMID: 29890265).

Formulation, Preparation, and Storage

Purification

Tissue culture supernatant

Formulation

Supernatant, 0.7% BSA

Preservative

0.1% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: MRP3

The protein encoded by the MRP3 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. (provided by RefSeq)

Long Name

ATP-binding cassette sub-family C member 3

Alternate Names

ABCC3, CMOAT2, EC 7.6.2.3, MLP2, MOAT-D

Gene Symbol

ABCC3

Additional MRP3 Products

Product Documents for MRP3 Antibody (M3II-21)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for MRP3 Antibody (M3II-21)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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