mu Opioid R/OPRM1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-31180

Novus Biologicals, part of Bio-Techne
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NBP1-31180
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Predicted:

Rhesus Macaque (93%). Backed by our 100% Guarantee.

Applications

Validated:

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all mu Opioid R/OPRM1 Antibodies »

Product Specifications

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human mu Opioid R/OPRM1. The exact sequence is proprietary.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Pig (86%), Chimpanzee (86%), Bovine (86%).

Localization

Cell membrane, Multi-pass membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for mu Opioid R/OPRM1 Antibody

Western Blot: mu Opioid R/OPRM1 Antibody [NBP1-31180]

Western Blot: mu Opioid R/OPRM1 Antibody [NBP1-31180]

Western Blot: mu Opioid R/OPRM1 Antibody [NBP1-31180] - Sample(30 ug of whole cell lysate) A:A431 B:H1299 7.5% SDS PAGE, antibody diluted at 1:500.
Immunocytochemistry/ Immunofluorescence: mu Opioid R/OPRM1 Antibody [NBP1-31180]

Immunocytochemistry/ Immunofluorescence: mu Opioid R/OPRM1 Antibody [NBP1-31180]

Immunocytochemistry/Immunofluorescence: mu Opioid R/OPRM1 Antibody [NBP1-31180] - MOR immunofluorescence in human astrocytes and microglia. MOR and GFAP co-localization in subsets of primary human astrocytes (C) immunofluorescence in subpopulations of primary human microglia (ScienCell; catalog number 1900-f1) cultured as described for astrocytes. Cells were fixed with 3.7% paraformaldehyde, permeabilized with 0.5% Triton X-100, immuno-labeled, nuclei were stained with DAPI (blue). Primary antibodies used at a 1:200 dilution. Images were acquired using a Zeiss LSM 700 laser scanning confocal microscope at 63x (1.42 NA) magnification and ZEN 2010 software (Carl Zeiss Inc, Thornwood, NY), and edited using ZEN 2009 Light Edition (Zeiss) and Adobe Photoshop CS3 Extended 10.0 software (Adobe Systems, Inc.). Image collected and cropped by CiteAb from the following publication (pubmed.ncbi.nlm.nih.gov/22591368/), licensed under a CC-BY license.
Immunohistochemistry-Paraffin: mu Opioid R/OPRM1 Antibody [NBP1-31180]

Immunohistochemistry-Paraffin: mu Opioid R/OPRM1 Antibody [NBP1-31180]

Immunohistochemistry-Paraffin: mu Opioid R/OPRM1 Antibody [NBP1-31180] - Cal27 xenograft, using mu Opioid receptor antibody at 1:500 dilution.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
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Applications for mu Opioid R/OPRM1 Antibody

Application
Recommended Usage

Flow Cytometry

Reported in scientific literature (PMID: 23751259).

Immunocytochemistry/ Immunofluorescence

Reported in scientific literature (PMID: 22591368).

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000

Reviewed Applications

Read 1 review rated 5 using NBP1-31180 in the following applications:

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS, 1% BSA, 20% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: mu Opioid R/OPRM1

Opioid receptors are the membrane proteins that mediate the pain-relieving effect of opioid drugs, such as morphine and fentanyl as well as endogenous opioid peptides enkephalins and endorphins. The effects of opiates are mediated through opioid receptors located on the plasma membrane of neurons and other peripheral cells. There are at least 3 types of opioid receptors, mu, kappa and delta, each with a distinct pharmacologic profile (1). The endogenous opioid system is involved in stress responses, in the regulation of the experience of pain, and in the action of analgesic opiate drugs. The activation of the mu-opioid receptor system was associated with reductions in the sensory and affective ratings of the pain experience, with distinct neuroanatomical involvements. Data demonstrate the central role of the mu-opioid receptors and their endogenous ligands in the regulation of sensory and affective components of the pain experience (2).

Long Name

mu Opioid Receptor

Alternate Names

LMOR, MOP, mOpioidR, MOR, MOR1, OPRM1

Gene Symbol

OPRM1

Additional mu Opioid R/OPRM1 Products

Product Documents for mu Opioid R/OPRM1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for mu Opioid R/OPRM1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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