Myelin PLP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-60071

Novus Biologicals, part of Bio-Techne
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NBP1-60071
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all Myelin PLP Antibodies »

Product Summary for Myelin PLP Antibody

Immunogen

Synthetic peptides corresponding to PLP1(proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)) The peptide sequence was selected from the N terminal of PLP1. Peptide sequence GHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGAL The peptide sequence for this immunogen was taken from within the described region.

Marker

Oligodendrocyte Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for Myelin PLP Antibody

Western Blot: Myelin PLP Antibody [NBP1-60071]

Western Blot: Myelin PLP Antibody [NBP1-60071]

Western Blot: Myelin PLP Antibody [NBP1-60071] - 721_B cell lysate, Antibody Titration: 0.2-1 ug/ml.
Immunohistochemistry-Paraffin: Myelin PLP Antibody [NBP1-60071]

Immunohistochemistry-Paraffin: Myelin PLP Antibody [NBP1-60071]

Immunohistochemistry-Paraffin: Myelin PLP Antibody [NBP1-60071] - Human Brain, cerebellum tissue at an antibody concentration of 5ug/ml.

Applications for Myelin PLP Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1.0 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Myelin PLP

PLP1 is a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

Long Name

Proteolipid Protein

Alternate Names

DM-20, Lipophilin, MMPL, PLP1, SPG2

Gene Symbol

PLP1

UniProt

P60201 (Human)

Additional Myelin PLP Products

Product Documents for Myelin PLP Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Myelin PLP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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