Myeloperoxidase/MPO Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87556

Novus Biologicals, part of Bio-Techne
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NBP1-87556
NBP1-87556-25ul
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Myeloperoxidase/MPO Antibodies »

Product Summary for Myeloperoxidase/MPO Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNC

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (89%), Rat (89%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Myeloperoxidase/MPO Antibody

Immunohistochemistry: Myeloperoxidase/MPO Antibody [NBP1-87556]

Immunohistochemistry: Myeloperoxidase/MPO Antibody [NBP1-87556]

Immunohistochemistry: Myeloperoxidase/MPO Antibody [NBP1-87556] - Staining of human spleen shows strong cytoplasmic positivity in subset of cells in red pulp .
Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody [NBP1-87556]

Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody [NBP1-87556]

Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody [NBP1-87556] - Staining of human cerebral cortex shows low expression as expected.
Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody [NBP1-87556]

Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody [NBP1-87556]

Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody [NBP1-87556] - Staining of human bone marrow shows high expression.
View 4 more images

Applications for Myeloperoxidase/MPO Antibody

Application
Recommended Usage

Immunohistochemistry

1:5000 - 1:10000

Immunohistochemistry-Paraffin

1:5000 - 1:10000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Myeloperoxidase/MPO

FUNCTION: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. MPO is an important marker for myeloid cells, from the promyelocyte stage and to the mature forms. CATALYTIC ACTIVITY: Donor + H2O2 = oxidized donor + 2 H2O. CATALYTIC ACTIVITY: Cl- + H2O2 = HOCl + 2 H2O. COFACTOR: Binds 1 calcium ion per heterodimer. COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer. SUBUNIT: Tetramer of two light chains and two heavy chains. SUBCELLULAR LOCATION: Lysosome. ALTERNATIVE PRODUCTS: 3 named isoforms produced by alternative splicing. DISEASE: Defects in MPO are the cause of myeloperoxidase deficiency (MPD). MPD is an autosomal recessive defect that results in disseminated candidiasis. SIMILARITY: Belongs to the peroxidase family. XPO subfamily.

Alternate Names

MPO

Gene Symbol

MPO

Additional Myeloperoxidase/MPO Products

Product Documents for Myeloperoxidase/MPO Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Myeloperoxidase/MPO Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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