Myotilin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-19455

Novus Biologicals, part of Bio-Techne
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NBP2-19455
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (95%), Mouse (93%), Porcine (95%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Myotilin Antibodies »

Product Summary for Myotilin Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human Myotilin. The exact sequence is proprietary.

Localization

Cell membrane; sarcolemma; Cytoplasm; cytoskeleton; myofibril; sarcomere; Z-disk

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Myotilin Antibody

Western Blot: Myotilin Antibody [NBP2-19455]

Western Blot: Myotilin Antibody [NBP2-19455]

Western Blot: Myotilin Antibody [NBP2-19455] - Sample (30 ug of whole cell lysate) A: A549 7. 5% SDS PAGE gel, diluted at 1:3000.
Immunohistochemistry-Paraffin: Myotilin Antibody [NBP2-19455]

Immunohistochemistry-Paraffin: Myotilin Antibody [NBP2-19455]

Immunohistochemistry-Paraffin: Myotilin Antibody [NBP2-19455] - Immunohistochemical analysis of paraffin-embedded hepatoma, using antibody at 1:500 dilution.

Applications for Myotilin Antibody

Application
Recommended Usage

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol, 1% BSA

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Myotilin

This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Alternate Names

57 kDa cytoskeletal protein, LGMD1A, limb-girdle muscular dystrophy 1A (autosomal dominant), Myofibrillar titin-like Ig domains protein, myotilin, Titin immunoglobulin domain protein, titin immunoglobulin domain protein (myotilin), TTIDLGMD1

Gene Symbol

MYOT

UniProt

Q9UBF9 (Human)

Additional Myotilin Products

Product Documents for Myotilin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Myotilin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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