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N-Acetylmannosamine Kinase/GNE Antibody (JE64-81)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-32397

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-32397

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # JE64-81

Concentration

1 mg/ml

Product Specifications

Immunogen

Synthetic peptide within human N-Acetylmannosamine Kinase/GNE aa 673-722/722. (Uniprot: Q9Y223)

Localization

Cytoplasm.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

79 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for N-Acetylmannosamine Kinase/GNE Antibody (JE64-81)

N-Acetylmannosamine Kinase/GNE Antibody (JE64-81)

Western Blot: N-Acetylmannosamine Kinase/GNE Antibody (JE64-81) [NBP3-32397]

Western Blot: N-Acetylmannosamine Kinase/GNE Antibody (JE64-81) [NBP3-32397] - Western blot analysis of N-Acetylmannosamine Kinase/GNE on different lysates with Rabbit anti-N-Acetylmannosamine Kinase/GNE antibody (NBP3-32397) at 1/500 dilution.

Lane 1: SW480 cell lysate
Lane 2: A549 cell lysate
Lane 3: Hela cell lysate

Lysates/proteins at 10 ug/Lane.

Predicted band size: 79 kDa
Observed band size: 79 kDa

Exposure time: 2 minutes;

10% SDS-PAGE gel.

Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (NBP3-32397) at 1/500 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody at 1:300,000 dilution was used for 1 hour at room temperature.

Applications for N-Acetylmannosamine Kinase/GNE Antibody (JE64-81)

Application
Recommended Usage

Western Blot

1:500

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

1*TBS (pH7.4), 0.05% BSA and 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: N-Acetylmannosamine Kinase/GNE

The protein encoded by the GNE gene is a bifunctional enzyme that monitors and begins biosynthesis of N-acetylneuraminic acid (NeuAc). NeuAC is a precursor of sialic acids and functions in early development as sialylation is a component of cell adhesion, signal transduction, and tumorigencity and metastic behavior of malignant cells. The GNE gene has been linked to various diseases such as: myopathy, dementia, glomerulosclerosis, muscular dystrophy, and neuromuscular disease. This protein creates an enzyme that is rate-limiting in the sialic acid biosynthetic pathway as well as plays a role in amino and nucleotide sugar metabolism as well as CMP-N-acetylneuraminate biosynthesis in eukaryotes. The GNE gene is known to interact with genes CRMP1. ZBTB16, PIK3C2A, KIAA1549, and RIF1 to participate in these pathways. GNE exists is five isoforms: isoform 1: 722 amino acids long; 79 kDA; isoform 2: 753 amino acids long, 83 kDA; isoform 3: 681 amino acids long; 74 kDA; isoform 4: 648 amino acids long, 71 kDA; isoform 5: 612 amino acids long, 66 kDA.

Long Name

Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine Kinase

Alternate Names

DMRV, GLCNE, GNE, IBM2, NAcetylmannosamine Kinase, Uae1

Gene Symbol

GNE

Additional N-Acetylmannosamine Kinase/GNE Products

Product Documents for N-Acetylmannosamine Kinase/GNE Antibody (JE64-81)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for N-Acetylmannosamine Kinase/GNE Antibody (JE64-81)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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