NALP6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-31372

Novus Biologicals, part of Bio-Techne
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NBP2-31372
NBP2-31372SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human, Mouse

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all NLRP6/NALP6 Antibodies »

Product Specifications

Immunogen

Partial recombinant protein made to an N-terminal portion of human NALP6 (between amino acids 10-200) [UniProt P59044].

Reactivity Notes

Immunogen sequence similarity with other species: Rat (72%), Mouse (70%). Use in Mouse reported in scientific literature (PMID:32682010).

Localization

Cytoplasm, Nucleus and Cell membrane

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NALP6 Antibody

Western Blot: NALP6 Antibody [NBP2-31372]

Western Blot: NALP6 Antibody [NBP2-31372]

Western Blot: NALP6 Antibody [NBP2-31372] - WB detection of NALP6 protein (NACHT, LRR and PYD domains-containing protein 6) in (A) Jurkat cells lysate and (B) partial recombinant protein using NALP6 antibody at a concentration of 1 ug/ml for lysate and 0.1 ug/ml for the recombinant protein. In Jurkat cells lysate, this antibody detected a major band at ~98.8 kDa which the expected position for NALP6.
Immunohistochemistry-Paraffin: NALP6 Antibody [NBP2-31372]

Immunohistochemistry-Paraffin: NALP6 Antibody [NBP2-31372]

Immunohistochemistry-Paraffin: NALP6 Antibody [NBP2-31372] - IHC-P analysis of NALP6 protein in a section of human breast normal tissue using NALP6 antibody at a concentration of 5 ug/ml. The breast ductal /acinar epithelium showed a strong NALP6 positivity in the cytoplasm and nuclei of the cells.

Applications for NALP6 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

reported in scientific literature (PMID 29928676)

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NLRP6/NALP6

NALP6 / NLRP6 (NACHT, LRR and PYD domains-containing protein 6) belongs to NLRP family of proteins - NLRP1, NLRP3, NLRC4 and NLRP6 - which functions as innate sensors of endogenous/exogenous stress or damage-associated molecular patterns (DAMPs). NLRPs are vital components of inflammasomes which are the cytoplasmic multi-protein complexes that coordinate several functions during inflammation and homeostasis in various type of cells/tissues. NLRP6 is a newly characterized NLR protein which is highly expressed in the intestinal epithelium as well as the granulocytes, and to a relatively lower levels on T-cells. NALP6 acts as an arginine-vasopressin V2 receptor and has been suggested to contribute to AVP-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. It implicates in the activation of CASP1 via ASC, promotion of NFkB activation and cAMP accumulation stimulation. NALP6 has been shown to actively participate in inflammasome signaling and to play critical roles in defense against infection, auto-inflammation and tumorigenesis.

Long Name

NLR Family, Pyrin Domain Containing 6

Alternate Names

AVR, CLR11.4, NALP6, NAVR, PAN3, PYPAF5

Entrez Gene IDs

171389 (Human)

Gene Symbol

NLRP6

UniProt

P59044

Additional NLRP6/NALP6 Products

Product Documents for NALP6 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for NALP6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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