Nav1.5 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB600-804

Novus Biologicals, part of Bio-Techne
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NB600-804
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Nav1.5 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-ETDDQSPEKIN, corresponding to the internal region according to NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1.

Specificity

This antibody is expected to recognise all reported isoforms (NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Nav1.5 Antibody

Immunohistochemistry-Paraffin: Nav1.5 Antibody [NB600-804]

Immunohistochemistry-Paraffin: Nav1.5 Antibody [NB600-804]

Immunohistochemistry-Paraffin: Nav1.5 Antibody [NB600-804] - Staining (8ug/ml) of paraffin embedded Human Cortex. Heat induced antigen retrieval with citrate buffer pH 6, HRP-Staining.
Immunohistochemistry-Paraffin: Nav1.5 Antibody [NB600-804]

Immunohistochemistry-Paraffin: Nav1.5 Antibody [NB600-804]

Immunohistochemistry-Paraffin: Nav1.5 Antibody [NB600-804] - Negative Control showing staining of paraffin embedded Human Cortex, with no primary antibody.

Applications for Nav1.5 Antibody

Application
Recommended Usage

Immunohistochemistry

8 - 10 ug/mL

Immunohistochemistry-Paraffin

8 - 10 ug/mL

Peptide ELISA

Detection limit 1:2000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Nav1.5

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in two transcript variants encoding separate isoforms which differ by a single amino acid. Mutation nomenclature has been assigned with respect to the longer isoform. This antibody is expected to recognise both reported isoforms (NP_000326 and NP_932173).

Long Name

Sodium channel protein type 5 subunit alpha

Alternate Names

SCN5A

Entrez Gene IDs

6331 (Human)

Gene Symbol

SCN5A

UniProt

NP_932173.1 (Human)

Additional Nav1.5 Products

Product Documents for Nav1.5 Antibody

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Certificate of Analysis

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Product Specific Notices for Nav1.5 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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