Neprilysin/CD10 Antibody (2A1H5E1) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-47356

Novus Biologicals, part of Bio-Techne
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NBP1-47356-0.025ml
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 2A1H5E1

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Neprilysin/CD10 Antibodies »

Product Specifications

Immunogen

Purified recombinant fragment of human CD-10 expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for Neprilysin/CD10 Antibody (2A1H5E1) - BSA Free

Immunohistochemistry-Paraffin: Neprilysin/CD10 Antibody (2A1H5E1) - BSA Free [NBP1-47356]

Immunohistochemistry-Paraffin: Neprilysin/CD10 Antibody (2A1H5E1) - BSA Free [NBP1-47356]

Immunohistochemistry-Paraffin: Neprilysin/CD10 Antibody (2A1H5E1) [NBP1-47356] - Analysis of human breast ductal myoepithelium (A) and lymph tissue (B), showing cytoplasmic (A) and membrane (B) localization using CD10 mouse mAb with DAB staining (A) and AEC staining (B).

Applications for Neprilysin/CD10 Antibody (2A1H5E1) - BSA Free

Application
Recommended Usage

ELISA

1:10000

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1000

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.03% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Neprilysin/CD10

This antibody recognizes human CD10 (CALLA, NEP, enkephalinase, Neprilysin), which is a 100 kDa, type II cell surface glycoprotein originally identified for its expression on most acute lymphoblastic leukemias (ALL). Subsequently, CD10 was shown to be the same molecule as the neutral endopeptidase (NEP), or KII-NA. CD10 is a Zn2+-dependent metallo-peptidase with endothelin, glucagon, gastrin, neurotensin and bradykinin included among its substrates. CD10 is involved in the regulation of chemotactic and inflammatory processes involving neutrophils. In B cells, CD10 regulates stromal cell-dependent B lymphopoiesis and expression has also been reported on mature B cells in germinal centres. In addition to the hematopoietic compartment, other major sites of CD10 expression are the brush border of enterocytes and renal tubules and glomeruli. There is partial blocking of CB-CALLA and MEM-78 monoclonal antibodies indicating that they recognize similar epitopes.

Alternate Names

CALLA, CD10, Enkephalinase, Leu-19, MME, Neutral Endopeptidase 24.11, NKH1

Entrez Gene IDs

4311 (Human)

Gene Symbol

MME

Additional Neprilysin/CD10 Products

Product Documents for Neprilysin/CD10 Antibody (2A1H5E1) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Neprilysin/CD10 Antibody (2A1H5E1) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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