Neuregulin-1/NRG1 Antibody (NRG1/2710)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-07721

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin, Protein Array

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # NRG1/2710

Concentration

0.2 mg/ml

View all Neuregulin-1/NRG1 Antibodies »

Product Specifications

Immunogen

Recombinant fragment of human Neuregulin-1/NRG1 protein (around aa 21-242) (exact sequence is proprietary) (Uniprot: Q02297)

Localization

Cell Surface and Cytoplasmic (Secreted)

Marker

Breast and Urothelial Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP3-08715)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.

Scientific Data Images for Neuregulin-1/NRG1 Antibody (NRG1/2710)

Immunohistochemistry-Paraffin: Neuregulin-1/NRG1 Antibody (NRG1/2710) [NBP3-07721]

Immunohistochemistry-Paraffin: Neuregulin-1/NRG1 Antibody (NRG1/2710) [NBP3-07721]

Immunohistochemistry-Paraffin: Neuregulin-1/NRG1 Antibody (NRG1/2710) [NBP3-07721] - Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Neuregulin-1/NRG1 Mouse Monoclonal Antibody (NRG1/2710).
Protein Array: Neuregulin-1/NRG1 Antibody (NRG1/2710) [NBP3-07721]

Protein Array: Neuregulin-1/NRG1 Antibody (NRG1/2710) [NBP3-07721]

Protein Array: Neuregulin-1/NRG1 Antibody (NRG1/2710) [NBP3-07721] - Analysis of Protein Array containing more than 19,000 full-length human proteins using Neuregulin-1/NRG1 Mouse Monoclonal Antibody (NRG1/2710).

Applications for Neuregulin-1/NRG1 Antibody (NRG1/2710)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2 ug/ml
Application Notes
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes.
Optimal dilution for a specific application should be determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Neuregulin-1/NRG1

Neuregulin 1 (NRG1, isoform HRG-beta2) belongs to the neuregulin/heregulin cytokine family consisting of variants of the four genes NRG1, NRG2, NRG3 and NRG4. More than 15 transmembrane and secreted protein isoforms exist for NRG1, they are generated by alternative promoter usage and mRNA splicing. The different isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. The EGF-like domain interacts with ErbB3 and ErbB4 tyrosine kinase receptors, resulting in tyrosine phosphorylation and NRG1 signaling. NRG proteins show distinct spatial and temporal expression patterns. These proteins are important for the development of the nervous system and the heart and in the regulation of neurotransmission.

Alternate Names

Heregulin-1, HGL, HRG1-alpha, HRG1-beta 1, Neuregulin1, NRG1

Gene Symbol

NRG1

UniProt

Q02297

Additional Neuregulin-1/NRG1 Products

Product Documents for Neuregulin-1/NRG1 Antibody (NRG1/2710)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Neuregulin-1/NRG1 Antibody (NRG1/2710)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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