Neuregulin-3/NRG3 Antibody (06) [Janelia Fluor® 549]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-06610JF549

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA

Label

Janelia Fluor 549

Antibody Source

Monoclonal Mouse IgG1 Clone # 06

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Neuregulin-3/NRG3 Antibodies »

Product Summary for Neuregulin-3/NRG3 Antibody (06) [Janelia Fluor® 549]

Immunogen

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Neuregulin-3/NRG3 (Accession#: ADK90021.1; Glu282-Pro342).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Neuregulin-3/NRG3 Antibody (06) [Janelia Fluor® 549]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Neuregulin-3/NRG3

NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

Alternate Names

Neuregulin3, NRG3

Gene Symbol

NRG3

Additional Neuregulin-3/NRG3 Products

Product Documents for Neuregulin-3/NRG3 Antibody (06) [Janelia Fluor® 549]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Neuregulin-3/NRG3 Antibody (06) [Janelia Fluor® 549]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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