Neuregulin-3/NRG3 Antibody (6V9X1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15901

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15901-100ul
NBP3-15901-20ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 6V9X1

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Neuregulin-3/NRG3 Antibodies »

Product Summary for Neuregulin-3/NRG3 Antibody (6V9X1)

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 600-720 of human Neuregulin-3 (Neuregulin-3/NRG3) (P56975). IIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSALTK

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Neuregulin-3/NRG3 Antibody (6V9X1)

Western Blot: Neuregulin-3/NRG3 Antibody (6V9X1) [NBP3-15901]

Western Blot: Neuregulin-3/NRG3 Antibody (6V9X1) [NBP3-15901]

Western Blot: Neuregulin-3/NRG3 Antibody (6V9X1) [NBP3-15901] - Western blot analysis of extracts of various cell lines, using Neuregulin-3 (Neuregulin-3/NRG3) antibody (NBP3-15901) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Western Blot: Neuregulin-3/NRG3 Antibody (6V9X1) [NBP3-15901]

Western Blot: Neuregulin-3/NRG3 Antibody (6V9X1) [NBP3-15901]

Western Blot: Neuregulin-3/NRG3 Antibody (6V9X1) [NBP3-15901] - Western blot analysis of extracts of various cell lines, using Neuregulin-3 (Neuregulin-3/NRG3) antibody (NBP3-15901) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.

Applications for Neuregulin-3/NRG3 Antibody (6V9X1)

Application
Recommended Usage

Western Blot

1:500 - 1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Neuregulin-3/NRG3

NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

Alternate Names

Neuregulin3, NRG3

Gene Symbol

NRG3

Additional Neuregulin-3/NRG3 Products

Product Documents for Neuregulin-3/NRG3 Antibody (6V9X1)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Neuregulin-3/NRG3 Antibody (6V9X1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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