Nicalin Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-81860

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all Nicalin Antibodies »

Product Specifications

Immunogen

Nicalin antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human Nicalin. The immunogen is located within amino acids 390 - 440 of Nicalin. Amino Acid Squence: MDVRSRVDSKTLTRNTRI

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Nicalin Antibody - BSA Free

Western Blot: Nicalin AntibodyBSA Free [NBP2-81860]

Western Blot: Nicalin AntibodyBSA Free [NBP2-81860]

Western Blot: Nicalin Antibody [NBP2-81860] - Western blot analysis of Nicalin in mouse heart tissue lysate with Nicalin antibody at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry/ Immunofluorescence: Nicalin Antibody - BSA Free [NBP2-81860]

Immunocytochemistry/ Immunofluorescence: Nicalin Antibody - BSA Free [NBP2-81860]

Immunocytochemistry/Immunofluorescence: Nicalin Antibody [NBP2-81860] - Immunofluorescence of Nicalin in human heart tissue with Nicalin antibody at 20 ug/mL.
Immunohistochemistry: Nicalin Antibody - BSA Free [NBP2-81860]

Immunohistochemistry: Nicalin Antibody - BSA Free [NBP2-81860]

Immunohistochemistry: Nicalin Antibody [NBP2-81860] - Immunohistochemistry of Nicalin in human heart tissue with Nicalin antibody at 2.5 ug/mL.
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Applications for Nicalin Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

2.5 ug/ml

Immunohistochemistry

2.5 ug/ml

Western Blot

0.5 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Nicalin

Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex. Nicalin, a Nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator). Nodals are TGFbeta signaling factors that control various cell fate decisions during embryonic body planning stages in vertebrate development. The Nicalin/NOMO complex acts to regulate the Nodal signaling factors during gastrulation. This regulation most often affects the development of the axial mesoderm. Nodal signaling is an important factor for melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype.

Alternate Names

Ncl-1, NCLN, NET59

Gene Symbol

NCLN

Additional Nicalin Products

Product Documents for Nicalin Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Nicalin Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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