NK3R/TACR3/Neurokinin B Receptor Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-82561

Novus Biologicals, part of Bio-Techne
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NBP1-82561
NBP1-82561-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all NK3R/TACR3 Antibodies »

Product Summary for NK3R/TACR3/Neurokinin B Receptor Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NK3R/TACR3/Neurokinin B Receptor Antibody

Immunohistochemistry-Paraffin: NK3R/TACR3/Neurokinin B Receptor Antibody [NBP1-82561]

Immunohistochemistry-Paraffin: NK3R/TACR3/Neurokinin B Receptor Antibody [NBP1-82561]

Immunohistochemistry-Paraffin: NK3R/TACR3/Neurokinin B Receptor Antibody [NBP1-82561] - Staining of human tonsil shows negative to very weak positivity in non-germinal center cells.
Immunohistochemistry-Paraffin: NK3R/TACR3/Neurokinin B Receptor Antibody [NBP1-82561]

Immunohistochemistry-Paraffin: NK3R/TACR3/Neurokinin B Receptor Antibody [NBP1-82561]

Immunohistochemistry-Paraffin: NK3R/TACR3/Neurokinin B Receptor Antibody [NBP1-82561] - Staining of human caudate nucleus shows moderate positivity in neurons and neuropil.
Immunohistochemistry-Paraffin: NK3R/TACR3/Neurokinin B Receptor Antibody [NBP1-82561]

Immunohistochemistry-Paraffin: NK3R/TACR3/Neurokinin B Receptor Antibody [NBP1-82561]

Immunohistochemistry-Paraffin: NK3R/TACR3/Neurokinin B Receptor Antibody [NBP1-82561] - Staining of human hyopthalmus shows moderate cytoplasmic positivity in neurons.
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Applications for NK3R/TACR3/Neurokinin B Receptor Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NK3R/TACR3

The Neurokinins, also known as Tachykinins, belong to an evolutionary conserved family of peptide neurotransmitters that share a c-terminal sequence and have an established role in neurotransmission. The mammalian tachykinins include substance P (NK1), neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.

Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).

Long Name

Neurokinin-3 Receptor

Alternate Names

Neurokinin B Receptor, Neuromedin-K Receptor, TAC3RL, TACR3

Entrez Gene IDs

6870 (Human)

Gene Symbol

TACR3

UniProt

P29371 (Human)

Additional NK3R/TACR3 Products

Product Documents for NK3R/TACR3/Neurokinin B Receptor Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for NK3R/TACR3/Neurokinin B Receptor Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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