Key Product Details

Species Reactivity

Human, Mouse, Rat, Porcine, Bovine, Canine, Equine, Primate, Xenopus

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 184C278

Concentration

0.5 mg/ml

View all NKIRAS1 Antibodies »

Product Specifications

Immunogen

This monoclonal antibody was raised against a synthetic peptide containing amino acid residues 96-113 (RVELLKKEIDKFKDKKEV) of human kB-Ras1.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for NKIRAS1 Antibody (184C278)

Western Blot: NKIRAS1 Antibody (184C278) [NB100-56555]

Western Blot: NKIRAS1 Antibody (184C278) [NB100-56555]

Western Blot: NKIRAS1 Antibody (184C278) [NB100-56555] - Analysis of human 293 cell lysate probed using 0.5 ug/ml. Image using the Azide Free form of this antibody.
Western Blot: NKIRAS1 Antibody (184C278) [NB100-56555]

Western Blot: NKIRAS1 Antibody (184C278) [NB100-56555]

Western Blot: NKIRAS1 Antibody (184C278) [NB100-56555] - Analysis of NKIRAS1 using this antibody. Human 293 cell lysate probed with kB-Ras1 antibody at 0.5 ug/ml.

Applications for NKIRAS1 Antibody (184C278)

Application
Recommended Usage

Western Blot

0.5-1 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NKIRAS1

NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. One of the first genes induced following NF-kB activation is IkBa. Recently, two proteins, kB-Ras1 and kB-Ras2 have been identified. These two proteins interact with PEST domains of IkBa and IkBb and decrease their rate of degradation.

Alternate Names

I-kappa-B-interacting Ras-like protein 1, kappa B-ras 1, Kappa B-Ras protein 1, KappaB-Ras1, KBRAS1kappaB-Ras1, NF-kappa-B inhibitor-interacting Ras-like protein 1, NFKB inhibitor interacting Ras-like 1, NFKB inhibitor interacting Ras-like protein 1

Entrez Gene IDs

28512 (Human)

Gene Symbol

NKIRAS1

UniProt

Q9NYS0 (Human)

Additional NKIRAS1 Products

Product Documents for NKIRAS1 Antibody (184C278)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for NKIRAS1 Antibody (184C278)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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