NKIRAS1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-17198

Novus Biologicals, part of Bio-Techne
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NBP3-17198-100ul
NBP3-17198-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (96%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all NKIRAS1 Antibodies »

Product Summary for NKIRAS1 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: KEQLHLYDTRGLQEGVELPKHYFSFAD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NKIRAS1 Antibody

Immunocytochemistry/ Immunofluorescence: NKIRAS1 Antibody [NBP3-17198]

Immunocytochemistry/ Immunofluorescence: NKIRAS1 Antibody [NBP3-17198]

Immunocytochemistry/Immunofluorescence: NKIRAS1 Antibody [NBP3-17198] - Staining of human cell line SH-SY5Y shows localization to cytosol & endoplasmic reticulum.
Immunohistochemistry-Paraffin: NKIRAS1 Antibody [NBP3-17198]

Immunohistochemistry-Paraffin: NKIRAS1 Antibody [NBP3-17198]

Immunohistochemistry-Paraffin: NKIRAS1 Antibody [NBP3-17198] - Staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.

Applications for NKIRAS1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence, PFA/Triton X-100 is recommended for fixation/permeabilization.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NKIRAS1

NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. One of the first genes induced following NF-kB activation is IkBa. Recently, two proteins, kB-Ras1 and kB-Ras2 have been identified. These two proteins interact with PEST domains of IkBa and IkBb and decrease their rate of degradation.

Alternate Names

I-kappa-B-interacting Ras-like protein 1, kappa B-ras 1, Kappa B-Ras protein 1, KappaB-Ras1, KBRAS1kappaB-Ras1, NF-kappa-B inhibitor-interacting Ras-like protein 1, NFKB inhibitor interacting Ras-like 1, NFKB inhibitor interacting Ras-like protein 1

Gene Symbol

NKIRAS1

Additional NKIRAS1 Products

Product Documents for NKIRAS1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for NKIRAS1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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