Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all NLRP5 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human NALP5. The immunogen is located within the last 50 amino acids of NALP5. Amino Acid Squence: WHSFDEDDRYWWKN

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NLRP5 Antibody - BSA Free

NLRP5 Antibody - BSA Free

Immunohistochemistry: NLRP5 Antibody - BSA Free [NBP1-76289] -

Immunohistochemistry: NLRP5 Antibody - BSA Free [NBP1-76289] - Immunohistochemistry of NLRP5 in human brain tissue with NLRP5 antibody at 10 u/mL.
Western Blot: NLRP5 AntibodyBSA Free [NBP1-76289]

Western Blot: NLRP5 AntibodyBSA Free [NBP1-76289]

Western Blot: NLRP5 Antibody [NBP1-76289] - Mouse brain tissue lysate with NLRP5 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
NLRP5 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: NLRP5 Antibody - BSA Free [NBP1-76289] -

Immunocytochemistry/ Immunofluorescence: NLRP5 Antibody - BSA Free [NBP1-76289] - Immunofluorescence of NLRP5 in human brain tissue with NLRP5 antibody at 20 u/mL.

Applications for NLRP5 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

10 ug/ml

Immunohistochemistry-Paraffin

10 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NLRP5

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.

Alternate Names

CLR19.8, MATERMater protein homolog, NACHT, leucine rich repeat and PYD containing 5, NACHT, LRR and PYD domains-containing protein 5, NALP5maternal antigen that embryos require, NLR family, pyrin domain containing 5, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 5, PAN11, PYPAF8

Gene Symbol

NLRP5

UniProt

NP_703148 (Human)

Additional NLRP5 Products

Product Documents for NLRP5 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for NLRP5 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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