Nse2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-56293

Novus Biologicals, part of Bio-Techne
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NBP1-56293
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

0.5 mg/ml

View all Nse2 Antibodies »

Product Specifications

Immunogen

Synthetic peptides corresponding to NSMCE2(non-SMC element 2, MMS21 homolog (S. cerevisiae)) The peptide sequence was selected from the middle region of NSMCE2. Peptide sequence KFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDE. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for Nse2 Antibody - BSA Free

Western Blot: Nse2 Antibody [NBP1-56293]

Western Blot: Nse2 Antibody [NBP1-56293]

Western Blot: Nse2 Antibody [NBP1-56293] - MCF-7 whole cell lysates, concentration 0.2-1 ug/ml.

Applications for Nse2 Antibody - BSA Free

Application
Recommended Usage

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Nse2

NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Alternate Names

C8orf36, E3 SUMO-protein ligase NSE2, EC 6.3.2, EC 6.3.2.-, FLJ32440, hMMS21, methyl methanesulfonate sensitivity gene 21, MMS21 homolog, MMS21chromosome 8 open reading frame 36, Non-SMC element 2 homolog, non-SMC element 2 homolog (MMS21, S. cerevisiae), non-SMC element 2, MMS21 homolog (S. cerevisiae), Non-structural maintenance of chromosomes element 2 homolog, NSE2

Gene Symbol

NSMCE2

UniProt

Q96MF7 (Human)

Additional Nse2 Products

Product Documents for Nse2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Nse2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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