Numb Antibody [Janelia Fluor® 525]

Novus Biologicals, part of Bio-Techne | Catalog # NB500-178JF525

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Product Datasheet / COA / SDS

View Available Conjugates

Conjugate

Catalog #

Unconjugated

NB500-178

Alexa Fluor 350

NB500-178AF350

Alexa Fluor 405

NB500-178AF405

Alexa Fluor 488

NB500-178AF488

Alexa Fluor 532

NB500-178AF532

Alexa Fluor 594

NB500-178AF594

Alexa Fluor 647

NB500-178AF647

Alexa Fluor 700

NB500-178AF700

Alexa Fluor 750

NB500-178AF750

Allophycocyanin

NB500-178APC

Biotin

NB500-178B

CoraFluor 1

NB500-178CL1

DyLight 350

NB500-178UV

DyLight 405

NB500-178V

DyLight 488

NB500-178G

DyLight 550

NB500-178R

DyLight 594

NB500-178DL594

DyLight 650

NB500-178C

DyLight 680

NB500-178FR

DyLight 755

NB500-178IR

FITC

NB500-178F

HRP

NB500-178H

Janelia Fluor 549

NB500-178JF549

Janelia Fluor 646

NB500-178JF646

Janelia Fluor 669

NB500-178JF669

mFluor Violet 450 SE

NB500-178MFV450

mFluor Violet 500 SE

NB500-178MFV500

mFluor Violet 610 SE

NB500-178MFV610

PE

NB500-178PE

PerCP

NB500-178PCP

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Chicken

Predicted:

Rat (90%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Simple Western, Western Blot

Label

Janelia Fluor 525

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Numb Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to a C-terminal region of mouse NUMB (between residues 600-653). [UniProt# Q9QZS3]

Reactivity Notes

Immunogen sequence has 90% identity to rat.

Localization

Membrane-associated

Specificity

This is specific for all four isoforms of the NUMB protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Numb Antibody [Janelia Fluor® 525]

Application

Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Simple Western

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Numb

Numb is a transmembrane signaling receptor that is activated by the DSL family of ligands. Studies suggestthat mammalian Numb plays a role in progenitor cell fate in neurogenesis. Numb exerts its role on cell fate by antagonizing Notch signaling. The mammalian Numb gene undergoes alternative splicing to produce at least four functionally different Numb isoforms which regulate different processes. A loss of Numb expression has been demonstrated in breast cancer, non-small cell lung cancer and chronic myelogenous leukemia.

Alternate Names

m-numb, mnb, S171

Gene Symbol

NUMB

Additional Numb Products

Product Documents for Numb Antibody [Janelia Fluor® 525]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for Numb Antibody [Janelia Fluor® 525]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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