OAS1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-58950

Novus Biologicals, part of Bio-Techne
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NBP1-58950
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all OAS1 Antibodies »

Product Specifications

Immunogen

Synthetic peptides corresponding to OAS1(2',5'-oligoadenylate synthetase 1, 40/46kDa) The peptide sequence was selected from the C terminal of OAS1. Peptide sequence GWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVRPPASSLPFIPAPLHEA. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for OAS1 Antibody

Western Blot: OAS1 Antibody [NBP1-58950]

Western Blot: OAS1 Antibody [NBP1-58950]

Western Blot: OAS1 Antibody [NBP1-58950] - OAS1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human heart
Immunohistochemistry-Paraffin: OAS1 Antibody [NBP1-58950]

Immunohistochemistry-Paraffin: OAS1 Antibody [NBP1-58950]

Immunohistochemistry-Paraffin: OAS1 Antibody [NBP1-58950] - Human tonsil tissue 5ug/ml

Applications for OAS1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: OAS1

OAS1 is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. It is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Mutations in this gene have been associated with host susceptibility to viral infection.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

Alternate Names

(2-5')oligo(A) synthase 1,2'-5'-oligoadenylate synthetase 1,2-5A synthase 1,2'-5'-oligoisoadenylate synthetase 1, (2-5')oligo(A) synthetase 1, 2'-5'-oligo A synthetase 1, 2'-5'-oligoadenylate synthase 1, 2'-5'-oligoadenylate synthetase 1 (40-46 kD), 2'-5'-oligoadenylate synthetase 1, 40/46kDa, E18/E16,2-5A synthetase 1, EC 2.7.7, EC 2.7.7.-, IFI-4,2'-5' oligoadenylate synthetase 1 p52 isoform, OIAS2'-5' oligoadenylate synthetase 1 p48 isoform, OIASI, p46/p42 OAS

Gene Symbol

OAS1

UniProt

P00973-2 (Human)

Additional OAS1 Products

Product Documents for OAS1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for OAS1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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