Oncostatin M/OSM Antibody (31E7)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26445

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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NBP3-26445-100ul
NBP3-26445-50ul
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Key Product Details

Species Reactivity

Human

Applications

ELISA

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # 31E7

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Oncostatin M/OSM Antibodies »

Product Specifications

Immunogen

Recombinant Human Oncostatin M/OSM protein [UniProt P13725]

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Scientific Data Images for Oncostatin M/OSM Antibody (31E7)

Oncostatin M/OSM Antibody (31E7)

ELISA: Oncostatin M/OSM Antibody (31E7) [NBP3-26445] -

ELISA: Oncostatin M/OSM Antibody (31E7) [NBP3-26445] - The Binding Activity of Human Oncostatin M/OSM with Oncostatin M/OSM Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human Oncostatin M/OSM at 2 ug/mL can bind Oncostatin M/OSM Antibody, the EC50 is 3.048-3.860 ng/mL.

Applications for Oncostatin M/OSM Antibody (31E7)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50% Glycerol, 0.01M PBS, PH 7.4

Preservative

0.03% Proclin 300

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: Oncostatin M/OSM

Oncostatin M is a 252 amino acid protein that is 28 kDa, acts as growth regulator inhibiting the proliferation of a number of tumor cell lines and stimulating the proliferation of AIDS-KS cells; regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells; uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST), and is involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. This protein is being studied for its involvement in several diseases and disorders including arterial occlusive disease, peripheral arterial occlusive disease, leukemia, kaposi's sarcoma, abdominal aortic aneurysm, status epilepticus, primary cutaneous amyloidosis, aortic aneurysm, bullous pemphigoid, neonatal jaundice, cutaneous malignant melanoma, plasmacytoma, systemic mastocytosis, mastocytosis, cervical squamous cell carcinoma, systemic lupus erythematosus, allergic rhinitis, squamous cell carcinoma, and lupus erythematosus. The protein has been linked to immune response IL-3 activation and signaling pathway, immune response oncostatin M signaling via JAK-Stat in human cells, development thrombopoetin signaling via JAK-STAT pathway, immune response Oncostatin M signaling via MAPK in human cells, MAPK signaling, endothelin-1 signaling pathway, molecular mechanisms of cancer, antioxidant action of vitamin-C, and Rho Family GTPases pathways where it interacts with IL6ST, TNNT1, LIFR, COL4A4, and COL4A6.

Alternate Names

MGC20461, oncostatin M, oncostatin-M

Gene Symbol

OSM

Additional Oncostatin M/OSM Products

Product Documents for Oncostatin M/OSM Antibody (31E7)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Oncostatin M/OSM Antibody (31E7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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