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OSMR beta Antibody (vixarelimab) - IgG4SP

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28875

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
Catalog #
Availability
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NBP3-28875-100ug
NBP3-28875-50ug

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG4 Clone # vixarelimab

Concentration

LYOPH mg/ml

Product Specifications

Immunogen

OSMR

Clonality

Monoclonal

Host

Human

Isotype

IgG4

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG4SP, and the light chain type is hulambda. It has a predicted MW of 145.5 kDa.

Also known as 'vixarelimab'.

IgG4SP is human IgG4 with S228P mutation.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for OSMR beta Antibody (vixarelimab) - IgG4SP

OSMR beta Antibody (vixarelimab) - IgG4SP

Functional: OSMR beta Antibody (vixarelimab) - IgG4SP[NBP3-28875] -

OSMR beta Antibody (vixarelimab) - IgG4SP P-STAT3 Assay was evaluated using NHDF. The IC50 was approximately 0.3493 nM.
OSMR beta Antibody (vixarelimab) - IgG4SP

Functional: OSMR beta Antibody (vixarelimab) - IgG4SP[NBP3-28875] -

OSMR beta Antibody (vixarelimab) - IgG4SP MCP-1 secretion was evaluated using NHDF. The IC50 was approximately 0.0812 nM.
OSMR beta Antibody (vixarelimab) - IgG4SP

ELISA: OSMR beta Antibody (vixarelimab) - IgG4SP[NBP3-28875] -

Immobilized human OSMR His at 2 ug/mL can bind OSMR beta Antibody (vixarelimab) - IgG4SP, EC50=0.0024 ug/mL.

Applications for OSMR beta Antibody (vixarelimab) - IgG4SP

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: OSMR beta

Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF [provided by RefSeq]

Long Name

Oncostatin M Receptor beta

Alternate Names

OSM R beta, OSMR, OSMRB

Gene Symbol

OSMR

UniProt

Additional OSMR beta Products

Product Documents for OSMR beta Antibody (vixarelimab) - IgG4SP

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for OSMR beta Antibody (vixarelimab) - IgG4SP

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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