Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁

Applications for p15INK4b/CDKN2B Antibody (OTI3B6) [Janelia Fluor® 549]

Application

Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: p15INK4b/CDKN2B

The normal progression of cells through the cell cycle is under the control of the cyclin dependent protein kinases Cdk4 and Cdk6 which are subject to inhibition by the mitotic inhibitory protein, p16. An isolated member of the p16 family has been designated p15. p15 expression is upregulated approximately 30-fold in TGFbeta-treated human keratinocytes, suggesting that p15 may act as an effector of TGFbeta-mediated cell cycle arrest. The gene encoding p15 has been mapped to chromosome 9p21 at a position adjacent to the p16 gene at a site of frequent chromosomal abnormality in human tumors. It has been suggested that p15 may function as an effector of TGFbeta-mediated cell cycle arrest through inhibition of Cdk4 and Cdk6 kinases.

Long Name

p15 Cyclin Dependent Kinase 4 Inhibitor 2B

Alternate Names

CDKN2B, MTS2

Gene Symbol

CDKN2B

Additional p15INK4b/CDKN2B Products

Product Documents for p15INK4b/CDKN2B Antibody (OTI3B6) [Janelia Fluor® 549]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for p15INK4b/CDKN2B Antibody (OTI3B6) [Janelia Fluor® 549]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

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Flow Cytometry

p15INK4b/CDKN2B Antibody (OTI3B6) [Janelia Fluor® 549]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-73184JF549

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Concentration

View all p15INK4b/CDKN2B Antibodies »

Product Specifications

Immunogen

Reactivity Notes

Clonality

Host

Isotype

Applications for p15INK4b/CDKN2B Antibody (OTI3B6) [Janelia Fluor® 549]

Flow Cytometry

Immunohistochemistry

Immunohistochemistry-Paraffin

Western Blot

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: p15INK4b/CDKN2B

Long Name

Alternate Names

Gene Symbol

Additional p15INK4b/CDKN2B Products

Product Documents for p15INK4b/CDKN2B Antibody (OTI3B6) [Janelia Fluor® 549]

Product Datasheets

COA

Certificate of Analysis

SDS

Product Specific Notices for p15INK4b/CDKN2B Antibody (OTI3B6) [Janelia Fluor® 549]

CONTACT INFORMATION

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