P2X7/P2RX7 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-37775

Novus Biologicals, part of Bio-Techne
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NBP1-37775
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human, Mouse

Predicted:

Canine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Cited:

IF/IHC, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all P2X7/P2RX7 Antibodies »

Product Specifications

Immunogen

Peptide with sequence YETNKVTRIQSMNY-C corresponding to N-Terminus according to NP_002553.2.

Epitope

N-Terminus

Reactivity Notes

Use in Mouse reported in scientific literature (PMID:34391810).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for P2X7/P2RX7 Antibody

Western Blot: P2X7/P2RX7 Antibody [NBP1-37775]

Western Blot: P2X7/P2RX7 Antibody [NBP1-37775]

Western Blot: P2X7/P2RX7 Antibody [NBP1-37775] - Staining of Human Brain (Frontal Cortex) lysate (35 ug protein in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Antibody at 0.3 ug/mL. Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: P2X7/P2RX7 Antibody [NBP1-37775]

Immunohistochemistry-Paraffin: P2X7/P2RX7 Antibody [NBP1-37775]

Immunohistochemistry-Paraffin: P2X7/P2RX7 Antibody [NBP1-37775] - Staining of paraffin embedded Human Kidney. Antibody at 3.75 ug/mL. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Immunohistochemistry-Paraffin: P2X7/P2RX7 Antibody [NBP1-37775]

Immunohistochemistry-Paraffin: P2X7/P2RX7 Antibody [NBP1-37775]

Immunohistochemistry-Paraffin: P2X7/P2RX7 Antibody [NBP1-37775] - Staining of paraffin embedded Human Brain Cortex. Antibody at 3.75 ug/mL. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for P2X7/P2RX7 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

3.75 ug/mL

Peptide ELISA

detection limit 1:16000

Western Blot

1 - 3 ug/mL
Application Notes
Use in ICC/IF reported in scientific literature (PMID:34391810)
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: P2X7/P2RX7

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq]

Long Name

P2X Purinergic Receptor 7

Alternate Names

P2RX7

Entrez Gene IDs

5027 (Human); 18439 (Mouse); 29665 (Rat)

Gene Symbol

P2RX7

UniProt

NP_002553.2 (Human)

Additional P2X7/P2RX7 Products

Product Documents for P2X7/P2RX7 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for P2X7/P2RX7 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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