p53 AIP1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76742

Novus Biologicals, part of Bio-Techne
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NBP1-76742
NBP1-76742-0.025mg
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

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Product Specifications

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human p53AIP1. The immunogen is located within the first 50 amino acids of p53AIP1. Amino Acid Squence: GSSSEASFRSAQASC

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for p53 AIP1 Antibody - BSA Free

Western Blot: p53 AIP1 AntibodyBSA Free [NBP1-76742]

Western Blot: p53 AIP1 AntibodyBSA Free [NBP1-76742]

Western Blot: p53 AIP1 Antibody [NBP1-76742] - HL60 cell lysate with p53AIP1 antibody at (A) 4 and (B) 8 u/mL.

Immunocytochemistry/Immunofluorescence: p53 AIP1 Antibody [NBP1-76742] -

Immunocytochemistry/Immunofluorescence: p53 AIP1 Antibody [NBP1-76742] - HL60 cells with p53AIP1 antibody at 10 ug/ml.

Immunocytochemistry/Immunofluorescence: p53 AIP1 Antibody [NBP1-76742] -

Immunocytochemistry/Immunofluorescence: p53 AIP1 Antibody [NBP1-76742] - Immunofluorescence of p53AIP1 in HL60 cells with p53AIP1 antibody at 20 ug/mL.
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Applications for p53 AIP1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10-20 ug/mL

Western Blot

4-8 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: p53 AIP1

The p53 tumor-suppressor protein can induce apoptosis through transcriptional activation of several genes. One such protein p53AIP was initially identified through direct cloning of p53 binding sequences from human genomic DNA. Its expression is inducible by p53 following p53 phosphorylation on Ser-46, and ectopic expression of p53AIP leads to apoptotic cell death. Both the phosphorylation of p53 and the induction of p53AIP were blocked by inhibiting the expression of p53DINP1 by the introduction of antisense oligonucleotides to p53DINP1, suggesting that the apoptosis associated with p53AIP expression is regulated by p53DINP1. Finally, as adenovirus-mediated introduction of p53AIP has been shown to suppress tumor growth in vivo, it has been suggested that p53AIP gene transfer may become a useful strategy for the treatment of p53-resistant cancers. Three isoforms of p53AIP are known to exist; this antibody will detect all three.

Alternate Names

p53AIP1, p53-regulated apoptosis-inducing protein 1, tumor protein p53 regulated apoptosis inducing protein 1

Gene Symbol

TP53AIP1

UniProt

BAB16421 (Human)

Additional p53 AIP1 Products

Product Documents for p53 AIP1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for p53 AIP1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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