p66 alpha Antibody (SR2093)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22399

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22399-100ul
NBP3-22399-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2093

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all p66 alpha Antibodies »

Product Summary for p66 alpha Antibody (SR2093)

Immunogen

A synthesized peptide derived from human p66 alpha (Uniprot #: Q86YP4)

Specificity

Detects endogenous levels of total p66 alpha

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for p66 alpha Antibody (SR2093)

Western Blot: p66 alpha Antibody (SR2093) [NBP3-22399] -

Western Blot: p66 alpha Antibody (SR2093) [NBP3-22399] - Western blot analysis using NBP3-22399 in K562 cell lysate.

Applications for p66 alpha Antibody (SR2093)

Application
Recommended Usage

Flow Cytometry

1:50

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: p66 alpha

Methylation of cytosine at CpG dinucleotides is a common feature of many higher eukaryotic genomes (1-3). Increasing evidence indicates that recruitement of histone deacetylase complexes by methyl-CpG-binding proteins (MeCP) is a major mechanism of methylated DNA silencing. P66, a zinc finger-containing protein is one of the components of the MeCP1 complex (4). P66 and p68, the two components of MeCP1 are different forms of the same zinc finger-containing protein and are conserved from C.elegans to humans. Homologs of p66 from different organisms revealed two highly conserved regions, CR1 and CR2. While CR1 is involved in the association of p66 with other MeCP1 components, CR2 plays an important role in targeting p66 and MBD3 to specific loci (4).

Alternate Names

FLJ20085, FLJ21017, GATA zinc finger domain containing 2A, GATA zinc finger domain-containing protein 2A, hp66alpha, p66 alpha, p66alpha, transcriptional repressor p66-alpha

Gene Symbol

GATAD2A

Additional p66 alpha Products

Product Documents for p66 alpha Antibody (SR2093)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for p66 alpha Antibody (SR2093)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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