pan-Synuclein Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-47338

Novus Biologicals, part of Bio-Techne
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NBP2-47338
NBP2-47338-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (93%), Rat (93%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all pan-Synuclein Antibodies »

Product Summary for pan-Synuclein Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: EGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for pan-Synuclein Antibody

Western Blot: pan-Synuclein Antibody [NBP2-47338]

Western Blot: pan-Synuclein Antibody [NBP2-47338]

Western Blot: pan-Synuclein Antibody [NBP2-47338] - Analysis in human cell lines SK-MEL-30 and MCF-7 using anti-SNCA antibody. Corresponding SNCA RNA-seq data are presented for the same cell lines. Loading control: anti-PFN1.
Immunohistochemistry-Paraffin: pan-Synuclein Antibody [NBP2-47338]

Immunohistochemistry-Paraffin: pan-Synuclein Antibody [NBP2-47338]

Immunohistochemistry-Paraffin: pan-Synuclein Antibody [NBP2-47338] - Staining in human cerebral cortex and liver tissues using anti-SNCA antibody. Corresponding SNCA RNA-seq data are presented for the same tissues.
Western Blot: pan-Synuclein Antibody [NBP2-47338]

Western Blot: pan-Synuclein Antibody [NBP2-47338]

Western Blot: pan-Synuclein Antibody [NBP2-47338] - Lane 1: Marker [kDa] 220, 112, 84, 47, 32, 26, 17. Lane 2: Human cell line RT-4
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Applications for pan-Synuclein Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: pan-Synuclein

Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1).

Alternate Names

Lewy body) 4, MGC110988, non A-beta component of AD amyloid, Non-A beta component of AD amyloid, non-A4 component of amyloid, Non-A4 component of amyloid precursor, PARK4, synuclein, alpha (non A4 component of amyloid precursor)

Gene Symbol

SNCA

Additional pan-Synuclein Products

Product Documents for pan-Synuclein Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for pan-Synuclein Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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