PANK2 Antibody (2B12)

Novus Biologicals, part of Bio-Techne | Catalog # H00080025-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 2B12

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PANK2 Antibodies »

Product Specifications

Immunogen

PANK2 (NP_705902, 205 a.a. ~ 259 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. IGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENPADSEKCQKLPFDLKNP

Reactivity Notes

Human. Other species not tested.

Specificity

PANK2 - pantothenate kinase 2 (Hallervorden-Spatz syndrome)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Scientific Data Images for PANK2 Antibody (2B12)

Immunohistochemistry-Paraffin: PANK2 Antibody (2B12) [H00080025-M01]

Immunohistochemistry-Paraffin: PANK2 Antibody (2B12) [H00080025-M01]

Immunohistochemistry-Paraffin: PANK2 Antibody (2B12) [H00080025-M01] - Analysis of monoclonal antibody to PANK2 on formalin-fixed paraffin-embedded human endometrium tissue. Antibody concentration 1 ~ 10 ug/ml.
Sandwich ELISA: PANK2 Antibody (2B12) [H00080025-M01] - Detection limit for recombinant GST tagged PANK2 is approximately 0.3ng/ml as a capture antibody.

Applications for PANK2 Antibody (2B12)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against recombinant protein for Western Blot. Has also been used for immunohistochemistry (paraffin) and ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: PANK2

This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.

Long Name

Pantothenate Kinase 2

Alternate Names

FLJ11729, HPANK2, NBIA1, PKAN

Entrez Gene IDs

80025 (Human)

Gene Symbol

PANK2

OMIM

234200 (Human)

UniProt

NP_705902 (Human)

Additional PANK2 Products

Product Documents for PANK2 Antibody (2B12)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PANK2 Antibody (2B12)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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