PARC Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-77222

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all PARC Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human PARC. The immunogen is located within the last 50 amino acids of PARC. Amino Acid Squence: DNDSFSYDESENLDQET

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PARC Antibody - BSA Free

Western Blot: PARC AntibodyBSA Free [NBP1-77222]

Western Blot: PARC AntibodyBSA Free [NBP1-77222]

Western Blot: PARC Antibody [NBP1-77222] - Daudi lysate with PARC antibody at (A) 1 and (B) 2 ug/ml.

Immunocytochemistry/Immunofluorescence: PARC Antibody [NBP1-77222] -

Immunocytochemistry/Immunofluorescence: PARC Antibody [NBP1-77222] - Daudi cells with PARC antibody at 1 ug/ml.

Immunocytochemistry/Immunofluorescence: PARC Antibody [NBP1-77222] -

Immunocytochemistry/Immunofluorescence: PARC Antibody [NBP1-77222] - Immunofluorescence of Bcl-G in Daudi cells with Bcl-G antibody at 2 ug/mL.
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Applications for PARC Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

1-2 ug/mL

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PARC

The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large, Parkin-like ubiquitin ligase has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promoted cytoplasmic sequestration of p53. Surprisingly, PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.

Alternate Names

CUL-9, cullin 9, cullin-9, DKFZp686G1042, H7AP1DKFZp686P2024, p53-associated parkin-like cytoplasmic protein, PARCKIAA0708, parkin-like cytoplasmic p53 binding protein, RP3-330M21.2, UbcH7-associated protein 1

Gene Symbol

CUL9

UniProt

NP_055904 (Human)

Additional PARC Products

Product Documents for PARC Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PARC Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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