Parkin [p Ser101] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-61106

Novus Biologicals, part of Bio-Techne
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NB100-61106
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Parkin Antibodies »

Product Specifications

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser101 conjugated to KLH. Accession # O60260

Modification

p Ser101

Specificity

Specific for the ~52 kDa parkin protein phosphorylated at Ser101. Immunolabeling of the parkin band is absent in parkin S101 mutants.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Parkin [p Ser101] Antibody

Western Blot: Parkin [p Ser101] Antibody [NB100-61106]

Western Blot: Parkin [p Ser101] Antibody [NB100-61106]

Western Blot: Parkin [p Ser101] Antibody [NB100-61106] - HEK293 cells transfected with Parkin WT (Phospho) and Parkin S101 mutant (non-phospho) showing the phospho-specific immunolabeling of the ~ 52 k parkin protein. The immunolabeling is absent in the parkin S101 mutant.

Applications for Parkin [p Ser101] Antibody

Application
Recommended Usage

Western Blot

1:1000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Parkin

Parkin is an E3 ligase in the ubiquitin-proteasome system. Hereditary Parkinsons disease is most commonly caused by mutations in the parkin gene and is characterized by the progressive loss of dopaminergic neurons and the presence of Lewy bodies in the substania nigra (Jenner aet al.,1992). Recent evidence suggests that phosphorylation of parkin at Ser101 may have an important regulatory role on its E3 ubiquitin ligase activity (Yamamoto et al., 2005).

Long Name

Parkinson Disease [autosomal recessive, juvenile] 2, Parkin [PARK2], transcript variant 1

Alternate Names

AR-JP, PARK2, PDJ, PRKN

Entrez Gene IDs

5071 (Human)

Gene Symbol

PRKN

UniProt

O60260 (Human)

Additional Parkin Products

Product Documents for Parkin [p Ser101] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Parkin [p Ser101] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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