Parkin Antibody [CoraFluor™ 1]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-41287CL1

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NBP2-41287AF350

Alexa Fluor 405

NBP2-41287AF405

Alexa Fluor 488

NBP2-41287AF488

Alexa Fluor 532

NBP2-41287AF532

Alexa Fluor 594

NBP2-41287AF594

Alexa Fluor 647

NBP2-41287AF647

Alexa Fluor 700

NBP2-41287AF700

Alexa Fluor 750

NBP2-41287AF750

Biotin

NBP2-41287B

DyLight 350

NBP2-41287UV

DyLight 405

NBP2-41287V

DyLight 488

NBP2-41287G

DyLight 550

NBP2-41287R

DyLight 594

NBP2-41287DL594

DyLight 650

NBP2-41287C

DyLight 680

NBP2-41287FR

DyLight 755

NBP2-41287IR

FITC

NBP2-41287F

HRP

NBP2-41287H

Janelia Fluor 525

NBP2-41287JF525

Janelia Fluor 549

NBP2-41287JF549

Janelia Fluor 646

NBP2-41287JF646

Janelia Fluor 669

NBP2-41287JF669

mFluor Violet 450 SE

NBP2-41287MFV450

mFluor Violet 500 SE

NBP2-41287MFV500

mFluor Violet 610 SE

NBP2-41287MFV610

PerCP

NBP2-41287PCP

Forumulation

Catalog #

BSA Free

NBP2-41287

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

CoraFluor 1

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Parkin Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 17 amino acid peptide near the amino terminus of human PARK2. The immunogen is located within amino acids 110 - 160 of PARK2. Amino Acid Squence: HTDSRKDSPPAGSPAG

Specificity

PARK2 antibody is human specific.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.

Applications for Parkin Antibody [CoraFluor™ 1]

Application

Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark. Do not freeze.

Background: Parkin

Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.

Long Name

Parkinson Disease [autosomal recessive, juvenile] 2, Parkin [PARK2], transcript variant 1

Alternate Names

AR-JP, PARK2, PDJ, PRKN

Gene Symbol

PRKN

Additional Parkin Products

Product Documents for Parkin Antibody [CoraFluor™ 1]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for Parkin Antibody [CoraFluor™ 1]

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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