Parvalbumin alpha Antibody (PVALB/7601)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26719

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # PVALB/7601

Concentration

0.2 mg/ml

View all Parvalbumin alpha Antibodies »

Product Specifications

Immunogen

Recombinant fragment (around aa1-110) of human Parvalbumin alpha protein (exact sequence is proprietary)

Localization

Nucleus, Cell junctions

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C. Non-hazardous. No MSDS required.

Scientific Data Images for Parvalbumin alpha Antibody (PVALB/7601)

Parvalbumin alpha Antibody (PVALB/7601)

Immunohistochemistry-Paraffin: Parvalbumin alpha Antibody (PVALB/7601) [NBP3-26719 ] -

Formalin-fixed, paraffin-embedded human kidney stained with Parvalbumin alpha Antibody (PVALB/7601). Inset: PBS instead of primary antibody; secondary only negative control.

Applications for Parvalbumin alpha Antibody (PVALB/7601)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2ug/ml for 30 minutes at RT
Application Notes
Immunohistochemistry-Paraffin 1-2ug/ml for 30 minutes at RT. Optimal dilution for a specific application should be determined.. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Parvalbumin alpha

Parvalbumin alpha is a 12 kDa member of the parvalbumin family of Ca2+-binding proteins. In human, it is expressed in intrafusal muscle fibers, plus GABAergic interneurons and cerebellar Purkinje and basket cells. It presumably acts as a Ca2+ buffer that shortens the duration of fiber contraction. Human Parvalbumin is 110 amino acids (aa) in length. It contains two EF-hand domains (aa 39 - 74 and 78 - 110) that bind calcium. There are three potential isoform variants. One shows an alternate start site at Met33, a second shows a six aa substitution for the C-terminal nine amino acids and a third shows a deletion of Gly99 - Val100. Human Parvalbumin alpha is 51% aa identical to human Parvalbumin beta and is 87% plus 92% aa identical to mouse and rat Parvalbumin, respectively.

Alternate Names

PVALB

Gene Symbol

PVALB

Additional Parvalbumin alpha Products

Product Documents for Parvalbumin alpha Antibody (PVALB/7601)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Parvalbumin alpha Antibody (PVALB/7601)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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