Paxillin Antibody (RM256)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61576

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM256

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Paxillin Antibodies »

Product Summary for Paxillin Antibody (RM256)

Immunogen

A peptide corresponding to the N-terminus of Human Paxillin

Reactivity Notes

This antibody may also react to mouse or rat Paxillin, as predicted by immunogen homology.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Paxillin Antibody (RM256)

Western Blot: Paxillin Antibody (RM256) [NBP2-61576]

Western Blot: Paxillin Antibody (RM256) [NBP2-61576]

Western Blot: Paxillin Antibody (RM256) [NBP2-61576] - Western Blot of HeLa cell lysate, using NBP2-61576.
Immunocytochemistry/ Immunofluorescence: Paxillin Antibody (RM256) [NBP2-61576]

Immunocytochemistry/ Immunofluorescence: Paxillin Antibody (RM256) [NBP2-61576]

Immunocytochemistry/Immunofluorescence: Paxillin Antibody (RM256) [NBP2-61576] - Immunocytochemical staining of HeLa cells, using Anti-Paxillin Rabbit monoclonal antibody Clone NBP2-61576 (red). Actin filaments have been labeled with fluorescein phalloidin (green), and nucleus labeled with DAPI (blue).
Immunohistochemistry-Paraffin: Paxillin Antibody (RM256) [NBP2-61576]

Immunohistochemistry-Paraffin: Paxillin Antibody (RM256) [NBP2-61576]

Immunohistochemistry-Paraffin: Paxillin Antibody (RM256) [NBP2-61576] - Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using NBP2-61576 at a 1:1000 dilution.

Applications for Paxillin Antibody (RM256)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:1000-1:2000

Immunohistochemistry

1:1000

Immunohistochemistry-Paraffin

1:1000

Western Blot

1:1000-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Paxillin

Paxillin is a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion) (1). Paxillin plays a significant role in integrin signaling and the tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization (2). Paxillin is phosphorylated by focal adhesion kinase (FAK) at Tyr118 (3). It has been found that phosphorylation of paxillin at both Tyr118 and Tyr31 is essential for MM1 cancer cell migration (4).

Alternate Names

PXN

Gene Symbol

PXN

Additional Paxillin Products

Product Documents for Paxillin Antibody (RM256)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Paxillin Antibody (RM256)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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