PDE1B Antibody (S03-6F9)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19732

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19732-100ul
NBP3-19732-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S03-6F9

Concentration

0.3 mg/ml

View all PDE1B Antibodies »

Product Summary for PDE1B Antibody (S03-6F9)

Immunogen

Recombinant protein of human PDE1B (Uniprot # Q01064)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

61 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PDE1B Antibody (S03-6F9)

Western Blot: PDE1B Antibody (S03-6F9) [NBP3-19732]

Western Blot: PDE1B Antibody (S03-6F9) [NBP3-19732]

Western Blot: PDE1B Antibody (S03-6F9) [NBP3-19732] - Western blot detection of PDE1B in Rat Brain lysates using NBP3-19732 (1:1000 diluted). Predicted band size: 61kDa. Observed band size: 61kDa.

Applications for PDE1B Antibody (S03-6F9)

Application
Recommended Usage

Western Blot

1/1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PDE1B

PDE1B, a variant of PDE1, is a Ca2+-calmodulin-stimulated phosphodieterase (PDE) preferentially hydrolyzing cGMP. Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. In mammals at least 11 different families of PDEs can be discriminated (PDE1-11) based on their kinetic properties and inhibition to various pharmacological agents. Three different PDE1 genes have been identified (PDE1A, PDE1B, PDE1C). The enzymes of the PDE1A and PDE1B have higher affinity for cGMP than for cAMP, whereas PDE1C has high affinity for both cAMP and cGMP. Calcium-Calmodulin stimulates the activity of each of these enzymes several-fold. The tissue distribution of PDE1B is different from other PDE1 gene family members. In testis PDE1B is expressed uniformly through out the seminiferous epithelium and in the interstistium in contrast to PDE1A and PDE1C that is expressed in elongated to mature spermatids.

Long Name

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

Alternate Names

63 kDa Cam-PDE, Cam-PDE 1B, PDES1B

Gene Symbol

PDE1B

Additional PDE1B Products

Product Documents for PDE1B Antibody (S03-6F9)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PDE1B Antibody (S03-6F9)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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