PDE4B Antibody (SR2301)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22387

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22387-100ul
NBP3-22387-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Flow Cytometry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2301

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PDE4B Antibodies »

Product Summary for PDE4B Antibody (SR2301)

Immunogen

A synthesized peptide derived from human PDE4B (Uniprot #: Q07343)

Specificity

Detects endogenous levels of total PDE4B

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

95 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PDE4B Antibody (SR2301)

Western Blot: PDE4B Antibody (SR2301) [NBP3-22387] -

Western Blot: PDE4B Antibody (SR2301) [NBP3-22387] - Western blot analysis using NBP3-22387 in A549 cell lysate.

Applications for PDE4B Antibody (SR2301)

Application
Recommended Usage

Flow Cytometry

1:50

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PDE4B

PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Enzymes of the cAMP-dependent phosphodiesterase type 4 (PDE4) family are important in hydrolyzing cAMP produced by G-protein coupled receptor (GPCR) stimulated adenylyl cyclases. Four genes (PDE4A, B, C and D) make up the PDE4 family. cAMP-dependent phosphodiesterase type B (PDE4B) family consists of four known splice variants, PDE4B1, B2, B3 and a novel 66 kDa PDE4B4 protein. One or more subtype variants of PDE4B are ubiquitously present in all mammalian cells. In CNS, all four PDE4B subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Some PDE4B variants are also substrate for PKA-dependent phosphorylation. Peripheral tissues exhibit differential expression of PDE4B1, B2 and B4 variants; the PDE4B4 (66kDa protein) is the major PDE4B variant expressed in lungs, testis and heart. In testis PDE4B enzymes are expressed in somatic cells (Sertoli and Leydig cells) while PDE4A is localized in germ cells.

Long Name

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Alternate Names

DPDE4, PDE32

Gene Symbol

PDE4B

Additional PDE4B Products

Product Documents for PDE4B Antibody (SR2301)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PDE4B Antibody (SR2301)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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