PDE5A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-86139

Novus Biologicals, part of Bio-Techne
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NBP1-86139
NBP1-86139-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Predicted:

Mouse (92%), Rat (91%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PDE5A Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: FAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGN

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PDE5A Antibody

Immunocytochemistry/ Immunofluorescence: PDE5A Antibody [NBP1-86139]

Immunocytochemistry/ Immunofluorescence: PDE5A Antibody [NBP1-86139]

Immunocytochemistry/Immunofluorescence: PDE5A Antibody [NBP1-86139] - Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: PDE5A Antibody [NBP1-86139]

Immunohistochemistry-Paraffin: PDE5A Antibody [NBP1-86139]

Immunohistochemistry-Paraffin: PDE5A Antibody [NBP1-86139] - Staining of human pancreas shows moderate cytoplasmic positivity in intercalated ducts.
Immunohistochemistry-Paraffin: PDE5A Antibody [NBP1-86139]

Immunohistochemistry-Paraffin: PDE5A Antibody [NBP1-86139]

Immunohistochemistry-Paraffin: PDE5A Antibody [NBP1-86139] - Staining of human liver shows no positivity in hepatocytes as expected.
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Applications for PDE5A Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF, Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PDE5A

PDE5A encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.

Long Name

cGMP-specific 3',5'-cyclic phosphodiesterase

Alternate Names

CGB-PDE, PDE5

Gene Symbol

PDE5A

Additional PDE5A Products

Product Documents for PDE5A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PDE5A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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