PDE6 beta Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB120-5663

Novus Biologicals, part of Bio-Techne
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NB120-5663
NB120-5663-0.025mg
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Bovine, Canine, Monkey

Cited:

Human, Primate - Macaca mulatta (Rhesus Macaque)

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Frozen

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all PDE6 beta Antibodies »

Product Specifications

Immunogen

Synthetic Peptides: H(20) Q Y F G (K/R) K L S P E N V A G A C(36)

Reactivity Notes

Use in Monkey reported in scientific literature (PMID:35024589) .

Localization

Plasma membrane

Specificity

Detects PDE6B from mouse retinal extracts.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PDE6 beta Antibody

Western Blot: PDE6 beta Antibody [NB120-5663]

Western Blot: PDE6 beta Antibody [NB120-5663]

Western Blot: PDE6 beta Antibody [NB120-5663] - Analysis of PDE6 beta. Lane 1 demostrates no detection on extracts of RD mice. Lane 2 shows a single band at ~90 kDa on Balb/C extracts.
Immunocytochemistry/ Immunofluorescence: PDE6 beta Antibody [NB120-5663]

Immunocytochemistry/ Immunofluorescence: PDE6 beta Antibody [NB120-5663]

Immunocytochemistry/Immunofluorescence: PDE6 beta Antibody [NB120-5663] - Mouse retina outer segments.
Immunohistochemistry-Frozen: PDE6 beta Antibody [NB120-5663]

Immunohistochemistry-Frozen: PDE6 beta Antibody [NB120-5663]

Immunohistochemistry-Frozen: PDE6 beta Antibody [NB120-5663] - Specific labeling of the photoreceptor outer segments with minimal background. Image from verified customer review.

Applications for PDE6 beta Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:10 - 1:500

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Frozen

1:10 - 1:500

Immunohistochemistry-Paraffin

1:10 - 1:500

Western Blot

2 ug/ml
Application Notes
WB: Detects an approx. 90 kDa protein.

Reviewed Applications

Read 1 review rated 4 using NB120-5663 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PDE6 beta

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Long Name

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Alternate Names

GMP-PDE beta, PDE6B, PDEB

Entrez Gene IDs

5158 (Human); 18587 (Mouse); 281974 (Bovine); 399653 (Canine)

Gene Symbol

PDE6B

UniProt

P23440 (Mouse)

Additional PDE6 beta Products

Product Documents for PDE6 beta Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PDE6 beta Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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