PDE6 beta Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-56205

Novus Biologicals, part of Bio-Techne
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NBP2-56205
NBP2-56205-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PDE6 beta Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEEST

Reactivity Notes

Mouse 81%

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PDE6 beta Antibody

Immunocytochemistry/ Immunofluorescence: PDE6 beta Antibody [NBP2-56205]

Immunocytochemistry/ Immunofluorescence: PDE6 beta Antibody [NBP2-56205]

Immunocytochemistry/Immunofluorescence: PDE6 beta Antibody [NBP2-56205] - Staining of human cell line SH-SY5Y shows localization to cytosol.
Immunohistochemistry-Paraffin: PDE6 beta Antibody [NBP2-56205]

Immunohistochemistry-Paraffin: PDE6 beta Antibody [NBP2-56205]

Immunohistochemistry-Paraffin: PDE6 beta Antibody [NBP2-56205] - Staining of human retina shows strong cytoplasmic positivity in photoreceptor cells and outer plexiform layer.

Applications for PDE6 beta Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PDE6 beta

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Long Name

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Alternate Names

GMP-PDE beta, PDE6B, PDEB

Gene Symbol

PDE6B

Additional PDE6 beta Products

Product Documents for PDE6 beta Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PDE6 beta Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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