PDE6A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB110-40461

Novus Biologicals, part of Bio-Techne
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NB110-40461
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Hamster, Monkey, Primate

Predicted:

Canine (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.23 mg/ml

View all PDE6A Antibodies »

Product Specifications

Immunogen

Synthetic 18 amino acid peptide from N-terminus of human PDE6A.

Epitope

N-Terminus

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Bovine (89%), Bat (89%), Equine (83%), Opossum (83%).

Localization

Cell membrane; Lipid-anchor; Cytoplasmic side.

Specificity

Human PDE6A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for PDE6A Antibody

Immunohistochemistry-Paraffin: PDE6A Antibody [NB110-40461]

Immunohistochemistry-Paraffin: PDE6A Antibody [NB110-40461]

Immunohistochemistry-Paraffin: PDE6A Antibody [NB110-40461] - Analysis of anti-PDE6A / PDE6 Alpha antibody with human eye, retina at concentration 10 ng/ml.

Applications for PDE6A Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

10-15 ug/ml
Application Notes
IHC: NB110-40461 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity..

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

0.23 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: PDE6A

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Long Name

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Alternate Names

GMP-PDE alpha, PDE V-B1, PDEA

Entrez Gene IDs

5145 (Human)

Gene Symbol

PDE6A

UniProt

P16499 (Human)

Additional PDE6A Products

Product Documents for PDE6A Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PDE6A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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