PDE8A Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB110-40457

Novus Biologicals, part of Bio-Techne
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NB110-40457
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Key Product Details

Species Reactivity

Validated:

Human, Porcine, Canine, Equine, Rabbit

Predicted:

Monkey (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all PDE8A Antibodies »

Product Specifications

Immunogen

Synthetic 16 aa peptide from near N-terminus of human PDE8A.

Epitope

near N-terminus of human

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (94%), Mouse (88%), Rat (88%), Bovine (88%), Opossum (88%), Zebrafish (81%).

Specificity

Human PDE8A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for PDE8A Antibody - BSA Free

Immunohistochemistry-Paraffin: PDE8A Antibody - BSA Free [NB110-40457]

Immunohistochemistry-Paraffin: PDE8A Antibody - BSA Free [NB110-40457]

Immunohistochemistry-Paraffin: PDE8A Antibody - BSA Free [NB110-40457] - Analysis of anti-PDE8A antibody with human prostate at concentration 10 ug/ml.

Applications for PDE8A Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

10 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: PDE8A

Phosphodiesterase type 8 (PDE8) is one of the many phosphodiesterases that compartmentalize and hydrolyze cAMP into AMP. The cAMP-specific PDE8 family is comprised of 2 genes (PDE8A and PDE8B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites. PDE8 family is a high affinity cAMP-specific, IBMX sensitive PDE. PDE8 has a significant conserved region of about 270 amino acids common to all PDEs at the carboxy terminal apparently serves as the catalytic domain. The amino-terminal region of this protein is divergent and presumably accounts for the distinctive and regulatory properties unique to the individual PDE families. PDE8A protein showed significant homology to other cAMP-dependent PDEs (23%) within the catalytic domain. PDE8A is widely expressed in various tissues in contrast to PDE8B that is exclusively expressed in thyroid gland. The PDE8A transcripts are found in brain, pancreas, placenta, thyroid, spleen, trachea, prostate, and uterus.

Long Name

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Alternate Names

cAMP-specific cyclic nucleotide phosphodiesterase 8A, EC 3.1.4.17, FLJ16150, high affinity cAMP-specific and IBMX-insensitive 3'-5'-cyclic phosphodiesterase8A, high-affinity cAMP-specific and IBMX-insensitive 3'-5'-cyclic phosphodiesterase8A, HsT19550, phosphodiesterase 8A

Entrez Gene IDs

5151 (Human)

Gene Symbol

PDE8A

Additional PDE8A Products

Product Documents for PDE8A Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PDE8A Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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