Pentraxin 2/SAP Antibody (APCS/3240)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-79714

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # APCS/3240

Concentration

0.2 mg/ml

View all Pentraxin 2/SAP Antibodies »

Product Specifications

Immunogen

Recombinant fragment of human Pentraxin 2/SAP protein (around aa 143-223) (exact sequence is proprietary) (Uniprot: P02743)

Localization

Secreted

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Description

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP2-79848)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.

Scientific Data Images for Pentraxin 2/SAP Antibody (APCS/3240)

Immunohistochemistry-Paraffin: Pentraxin 2/SAP Antibody (APCS/3240) [NBP2-79714]

Immunohistochemistry-Paraffin: Pentraxin 2/SAP Antibody (APCS/3240) [NBP2-79714]

Immunohistochemistry-Paraffin: Pentraxin 2/SAP Antibody (APCS/3240) [NBP2-79714] - Formalin-fixed, paraffin-embedded human Brain stained with Pentraxin 2/SAP Antibody (APCS/3240).
Protein Array: Pentraxin 2/SAP Antibody (APCS/3240) [NBP2-79714]

Protein Array: Pentraxin 2/SAP Antibody (APCS/3240) [NBP2-79714]

Protein Array: Pentraxin 2/SAP Antibody (APCS/3240) [NBP2-79714] - Analysis of Protein Array containing more than 19,000 full-length human proteins using Pentraxin 2/SAP Antibody (APCS/3240). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5

Applications for Pentraxin 2/SAP Antibody (APCS/3240)

Application
Recommended Usage

Immunohistochemistry

1-2 ug/ml

Immunohistochemistry-Paraffin

1-2 ug/ml
Application Notes
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes.
Optimal dilution for a specific application should be determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Pentraxin 2/SAP

Serum Amyloid P (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits and this is probably due to its specific calcium-dependent binding to motifs present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits (1,2). It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T lymphocytes or B lymphocytes (3). SAP production can be induced by exposure to IL-1, IL-6 and IFN-beta. The SAP-inducing activity was neutralized by antibodies to each of the recombinant cytokines (4).

Long Name

Serum Amyloid P Component

Alternate Names

APCS, PTX2, SAP

Gene Symbol

APCS

UniProt

P02743

Additional Pentraxin 2/SAP Products

Product Documents for Pentraxin 2/SAP Antibody (APCS/3240)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Pentraxin 2/SAP Antibody (APCS/3240)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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