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PERK Antibody (PSH0-81)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-32738

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-32738

Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # PSH0-81

Concentration

1 mg/ml

Product Summary for PERK Antibody (PSH0-81)

Immunogen

Recombinant protein within human PERK aa 51-450 / 1,116. (Uniprot: Q9NZJ5)

Localization

Endoplasmic reticulum membrane.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

125 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PERK Antibody (PSH0-81)

PERK Antibody (PSH0-81)

Western Blot: PERK Antibody (PSH0-81) [NBP3-32738]

Western Blot: PERK Antibody (PSH0-81) [NBP3-32738] - Western blot analysis of PERK on different lysates with Rabbit anti-PERK antibody (NBP3-32738) at 1/1,000 dilution.

Lane 1: MCF7 cell lysate (20 ug/Lane)
Lane 2: HepG2 cell lysate (20 ug/Lane)
Lane 3: HEK-293 cell lysate (20 ug/Lane)
Lane 4: HeLa cell lysate (20 ug/Lane)
Lane 5: A549 cell lysate (20 ug/Lane)
Lane 6: U-87 MG cell lysate (20 ug/Lane)
Lane 7: K-562 cell lysate (16 ug/Lane)

Predicted band size: 125 kDa
Observed band size: 140 kDa

Exposure time: 2 minutes;

4-20% SDS-PAGE gel.

Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (NBP3-32738) at 1/1,000 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody at 1:100,000 dilution was used for 1 hour at room temperature.

Applications for PERK Antibody (PSH0-81)

Application
Recommended Usage

Western Blot

1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH7.4), 0.1% BSA and 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PERK

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at Tyrosine 204 and 187 and Threonine 177 and 160 residues mapping within a characteristic Thr-Glu-Tyr motif. Phosphorylation at both the Threonine 202 and Tyrosine 204 residues of ERK 1 and Threonine 185 and Tyrosine 187 residues of ERK 2 is required for full enzymatic activation. The structural consequences of dual phosphorylation in ERK 2 include active site closure, alignment of key catalytic residues that interact with ATP, and remodeling of the activation loop. In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.

Long Name

Eukaryotic Translation Initiation Factor 4B

Alternate Names

EIF2AK3, PEK, WRS

Gene Symbol

EIF2AK3

Additional PERK Products

Product Documents for PERK Antibody (PSH0-81)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for PERK Antibody (PSH0-81)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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