PIBF1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-58835

Novus Biologicals, part of Bio-Techne
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NB100-58835
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Key Product Details

Validated by

Independent Antibodies, Biological Validation

Species Reactivity

Human

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all PIBF1 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 735 and 757 of human progesterone-induced-blocking factor 1 using the numbering given in entry NP_006337.2 (GeneID 10464).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PIBF1 Antibody

Western Blot: PIBF1 Antibody [NB100-58835]

Western Blot: PIBF1 Antibody [NB100-58835]

Western Blot: PIBF1 Antibody [NB100-58835] - Detection of Human PIBF1 on HeLa whole cell lysate using NB100-58835. PIBF1 was also immunoprecipitated by rabbit anti-PIBF1 antibody NB100-58834.

Applications for PIBF1 Antibody

Application
Recommended Usage

Immunoprecipitation

1:10-1:500

Western Blot

1:2000-1:10000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: PIBF1

PIBF (progesterone-induced blocking factor 1) is synthesized during pregnancy in response to progesterone by progesterone receptor-positive T lymphocytes (mostly gamma-delta T cells). In the presence of PIBF, natural killer (NK) cells inhibit the release of perforin from storage granules and, therefore, fail to lyse target cells. In humans, the amount of cells that express PIBF is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. PIBF has a predicted 89 kDa molecular mass; the full-length PIBF is associated with the nucleus, whereas secretion of shorter forms, such a 34 kDa protein is induced by activation of the cell. Research suggests that PIBF functions as a transcription factor in its full-length form, while smaller forms may act as cytokines.

Long Name

Progesterone Immunomodulatory Binding Factor 1

Alternate Names

C13orf24, chromosome 13 open reading frame 24, KIAA1008, PIBF, progesterone immunomodulatory binding factor 1, progesterone-induced blocking factor 1, progesterone-induced-blocking factor 1, RP11-505F3.1

Entrez Gene IDs

10464 (Human)

Gene Symbol

PIBF1

UniProt

NP_006337.2 (Human)

Additional PIBF1 Products

Product Documents for PIBF1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PIBF1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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