PIK3C2A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-855

Novus Biologicals, part of Bio-Techne
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NB300-855
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%), Mouse (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all PIK3C2A Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-TVKWYQLTAATYL corresponding to C-Terminus according to NP_002636.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for PIK3C2A Antibody

Immunohistochemistry-Paraffin: PIK3C2A Antibody [NB300-855]

Immunohistochemistry-Paraffin: PIK3C2A Antibody [NB300-855]

Immunohistochemistry-Paraffin: PIK3C2A Antibody [NB300-855] - (2ug/ml) staining of paraffin embedded Human Placenta. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.
Immunohistochemistry-Paraffin: PIK3C2A Antibody [NB300-855]

Immunohistochemistry-Paraffin: PIK3C2A Antibody [NB300-855]

Immunohistochemistry-Paraffin: PIK3C2A Antibody [NB300-855] - IHC analysis of PIK3C2A in paraffin embedded Human Heart using NB300-855 at 5ug/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for PIK3C2A Antibody

Application
Recommended Usage

Immunohistochemistry

5 - 10 ug/ml

Immunohistochemistry-Paraffin

1:10-1:500

Peptide ELISA

detection limit 1:32000
Application Notes
WB: Preliminary experiments gave no signal but low background in human testis and Molt-4 lysates at up to 1 ug/ml. IHC-P: Human heart shows strong staining of the capillary network and patterned staining of the myocardial fibres in transverse section.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PIK3C2A

PIK3C2A belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

Long Name

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Alternate Names

EC 2.7.1.137, EC 2.7.1.153, EC 2.7.1.154, PI3K-C2-alpha

Entrez Gene IDs

5286 (Human); 18704 (Mouse)

Gene Symbol

PIK3C2A

UniProt

NP_002636. (Human)

Additional PIK3C2A Products

Product Documents for PIK3C2A Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PIK3C2A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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