PKA 2 beta Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-80879

Novus Biologicals, part of Bio-Techne
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NBP1-80879
NBP1-80879-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (93%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PKA 2 beta Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: GFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIH

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PKA 2 beta Antibody

Immunohistochemistry-Paraffin: PKA 2 beta Antibody [NBP1-80879]

Immunohistochemistry-Paraffin: PKA 2 beta Antibody [NBP1-80879]

Immunohistochemistry-Paraffin: PKA 2 beta Antibody [NBP1-80879] - Analysis in human adipose tissue and skeletal muscle tissues using NBP1-80879 antibody. Corresponding PKA 2 beta RNA-seq data are presented for the same tissues.
Western Blot: PKA 2 beta Antibody [NBP1-80879]

Western Blot: PKA 2 beta Antibody [NBP1-80879]

Western Blot: PKA 2 beta Antibody [NBP1-80879] - Analysis in human cell line Daudi.
Immunohistochemistry-Paraffin: PKA 2 beta Antibody [NBP1-80879]

Immunohistochemistry-Paraffin: PKA 2 beta Antibody [NBP1-80879]

Immunohistochemistry-Paraffin: PKA 2 beta Antibody [NBP1-80879] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
View 3 more images

Applications for PKA 2 beta Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000

Western Blot

0.04 - 0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PKA 2 beta

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.

Long Name

cAMP-dependent protein kinase type II-beta regulatory subunit

Alternate Names

PRKAR2B

Entrez Gene IDs

5577 (Human)

Gene Symbol

PRKAR2B

UniProt

P31323 (Human)

Additional PKA 2 beta Products

Product Documents for PKA 2 beta Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PKA 2 beta Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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