PKA R2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38399

Novus Biologicals, part of Bio-Techne
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NBP2-38399
NBP2-38399-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (94%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PKA R2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: ERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCH

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PKA R2 Antibody

Immunocytochemistry/ Immunofluorescence: PKA R2 Antibody [NBP2-38399]

Immunocytochemistry/ Immunofluorescence: PKA R2 Antibody [NBP2-38399]

Immunocytochemistry/Immunofluorescence: PKA R2 Antibody [NBP2-38399] - Immunofluorescent staining of human cell line U-251 MG shows localization to microtubule organizing center.
Immunohistochemistry: PKA R2 Antibody [NBP2-38399]

Immunohistochemistry: PKA R2 Antibody [NBP2-38399]

Immunohistochemistry: PKA R2 Antibody [NBP2-38399] - Staining of human kidney shows strong cytoplasmic and membranous positivity in cells in tubules.

Applications for PKA R2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PKA R2

PKA (or cAPK) is a cyclic AMP-dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, and gene transcription (1,2). PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunits (RI and RII) have been identified, each possessing distinct cAMP binding properties and resulting in different phosphorylation states (2,3).

Alternate Names

protein kinase, cAMP-dependent, regulatory, type II, alpha, RII-alpha subunit

Gene Symbol

PRKAR2A

UniProt

P13861

Additional PKA R2 Products

Product Documents for PKA R2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PKA R2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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