PKC beta 2 Antibody (SR2824)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-27716

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-27716-50ul
NBP3-27716-100ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2824

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PKC beta 2 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human PKC beta 2 (Uniprot #: P05771)

Specificity

Detects endogenous levels of total PKC beta 2

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

77 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PKC beta 2 Antibody (SR2824)

Western Blot: PKC beta 2 Antibody (SR2824) [NBP3-27716] -

Western Blot: PKC beta 2 Antibody (SR2824) [NBP3-27716] - Western blot analysis of PKC beta 2 expression in K562 cell lysate.

Applications for PKC beta 2 Antibody (SR2824)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Immunoprecipitation

1:50

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 150mM NaCl, 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PKC beta 2

Members of the Protein Kinase C (PKC) family are serine/threonine protein kinases that play a key regulatory role in a number of cellular functions including cell growth and differentiation, hormone secretion, and gene expression. Multiple genes and alternative splicing result in three subfamilies, which differ in their co-factor requirements: conventional PKC isoforms (alpha, beta 1, beta 2, and gamma) which require calcium and phosphatidylserine (PS), diacylglycerol (DAG) or phorbol esters for activation; novel isoforms (delta, epsilon, eta, and theta), which are calcium-independent but are still regulated by PS, DAG, or phorbol esters; and atypical isoforms (iota/lambda and zeta), which are calcium-independent and do not require PS, DAG, or phorbol esters for activation. PKC beta 2 regulation of c-myc expression has been shown to suppress insulin gene transcription in pancreatic beta-cells implicating PKC beta 2 for some of the beta-cell glucose toxicity found in diabetes.

Long Name

Protein Kinase C beta 2

Alternate Names

PKCB;PKCbeta;PKC-beta;PKCI(2);PRKCB;PRKCB1;PRKCB2;Protein kinase C beta type

Gene Symbol

PRKCB

Additional PKC beta 2 Products

Product Documents for PKC beta 2 Antibody (SR2824)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PKC beta 2 Antibody (SR2824)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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